Search results for " multicentre"

showing 10 items of 12 documents

Interim 2017/18 influenza seasonal vaccine effectiveness: combined results from five European studies

2018

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates. Funding: The five studies have received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in…

0301 basic medicineMalePediatricsEpidemiologyvirusesInfluenza B viruinfluenza ; influenza vaccine effectiveness ; influenza vaccination ; case control study ; multicentre study ; EuropeEurope case control study influenza influenza vaccination influenza vaccine effectiveness multicentre study0302 clinical medicineInfluenza A Virus H1N1 Subtype[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesInteriminfluenza vaccine effectivenessEpidemiologyPandemicInfluenza A Virus030212 general & internal medicineQAInfluenza vaccine effectivenessChildmedia_commonVaccine EffectivenessVaccinationvirus diseasesMiddle Agedinfluenza vaccinationmulticentre study3. Good healthVaccinationEuropeTreatment OutcomeInfluenza VaccinesChild PreschoolH3N2 SubtypeFemaleSeasonsInfluenza VaccineinfluenzaRapid CommunicationHumanAdultRMmedicine.medical_specialtyAdolescentInfluenza vaccine030106 microbiologyCase control studyMulticentre studyEuropean studiesSettore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA03 medical and health sciencesVirologyInfluenza Humanmedicinemedia_common.cataloged_instanceHumansH1N1 SubtypeVacina AntigripalEuropean UnionEuropean unionPreschoolPandemicsAgedPandemicInfluenza A Virus H3N2 SubtypeCuidados de SaúdePublic Health Environmental and Occupational HealthInfant NewbornInfantInfluenza ainfluenza vaccine effectivenecase control studyNewbornEurope; case control study; influenza; influenza vaccination; influenza vaccine effectiveness; multicentre studyInfluenzarespiratory tract diseasesInfluenza vaccinationInfluenza B virusEurope; case control study; influenza; influenza vaccination; influenza vaccine effectiveness; multicentre study; Adolescent; Adult; Aged; Child; Child Preschool; Europe; European Union; Female; Humans; Infant; Infant Newborn; Influenza A Virus H1N1 Subtype; Influenza A Virus H3N2 Subtype; Influenza B virus; Influenza Vaccines; Influenza Human; Male; Middle Aged; Pandemics; Treatment Outcome; Vaccination; Seasons[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologieDeterminantes da Saúde e da Doença[SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology
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Could university training and a proactive attitude of coworkers be associated with influenza vaccination compliance? A multicentre survey among Itali…

2016

Background: Although influenza vaccination has been demonstrated to be safe and effective, vaccination coverage rates among health care workers and among medical residents appear generally low. Several investigations have been performed worldwide to analyze the healthcare workers' educational deficiencies. This multicentre survey aimed to investigate at a nationwide level training quality and work environment associated with seasonal influenza vaccination uptake among Italian medical residents. Methods: A retrospective cohort study was carried out from April 2012 to June 2012 on medical residents regularly attending the post-graduate medical schools of 18 Italian Universities via an anonymo…

AdultMaleInternetAttitude of Health Personnel3304Medicine (all)Internship and ResidencyInfluenza vaccinationUniversity trainingMedical residentItalyEducation Medical GraduateRetrospective StudieCoworkers attitude; Influenza vaccination; Medical residents; Multicentre survey; University training; Adult; Education Medical Graduate; Female; Humans; Influenza Vaccines; Influenza Human; Internet; Italy; Male; Patient Compliance; Retrospective Studies; Surveys and Questionnaires; Attitude of Health Personnel; Internship and Residency; Medicine (all); 3304Influenza HumanPatient ComplianceSurveys and QuestionnaireFemaleMulticentre surveyInfluenza VaccineCoworkers attitudeHuman
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IgA anti-actin antibodies ELISA in coeliac disease: A multicentre study.

2007

Previous studies have demonstrated that serum anti-actin antibodies are a reliable marker of intestinal damage severity in coeliac disease.To validate in a multicentre study the clinical usefulness of serum IgA anti-actin antibody ELISA and its possible use in monitoring intestinal mucosa lesions during gluten-free diet.Four centres recruited 205 newly diagnosed coeliac disease patients with villous atrophy, 80 healthy controls and 81 "disease" controls. Twelve coeliac disease patients on gluten-free diet but with persistent symptoms underwent serum IgA anti-actin antibody assay and intestinal histology evaluation. IgA anti-actin antibody ELISA was performed with a commercial kit. All coeli…

AdultMalePathologymedicine.medical_specialtySettore MED/09 - Medicina InternaAdolescentEnzyme-Linked Immunosorbent AssaySerum igaDiseaseCommercial kitSensitivity and SpecificityCoeliac diseaseIgA anti-actin antibodies; coeliac disease; multicentre studyIntestinal mucosaHumansMedicineIntestinal MucosaVillous atrophyChildAgedAutoantibodiesHepatologybiologybusiness.industryGastroenterologyInfantnutritional and metabolic diseasesMiddle AgedIgA anti-actin antibodiemedicine.diseaseActinsmulticentre studyImmunoglobulin ACeliac DiseaseIntestinal histologyChild Preschoolbiology.proteinFemaleAntibodybusinessBiomarkerscoeliac disease
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Influenza vaccination coverage among medical residents: An Italian multicenter survey

2014

Although influenza vaccination is recognized to be safe and effective, recent studies have confirmed that immunization coverage among health care workers remain generally low, especially among medical residents (MRs). Aim of the present multicenter study was to investigate attitudes and determinants associated with acceptance of influenza vaccination among Italian MRs. A survey was performed in 2012 on MRs attending post-graduate schools of 18 Italian Universities. Each participant was interviewed via an anonymous, self-administered, web-based questionnaire including questions on attitudes regarding influenza vaccination. A total of 2506 MRs were recruited in the survey and 299 (11.9%) of t…

AdultMalemedicine.medical_specialtyPediatricsAttitude of Health PersonnelImmunologySocio-culturaleSettore MED/42 - Igiene Generale E ApplicataInfluenza immunizationmedical residentsPhysiciansHealth careInfluenza Humanmedicineinfluenza vaccination; coverage rateImmunology and AllergyHumansGood practiceCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre survey; Adult; Female; Humans; Influenza Vaccines; Influenza Human; Italy; Male; Vaccination; Attitude of Health Personnel; Data Collection; Internship and Residency; Physiciansmulticentre surveyEthical responsibilityPharmacologyCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre surveybusiness.industryinfluenza vaccination; medical residents; multicentre survey; coverage rate; ItalyData CollectionVaccinationInternship and ResidencyItaly coverage rate influenza vaccination medical residents multicentre surveyInfluenzainfluenza vaccinationVaccinationMulticenter studyItalyInfluenza VaccinesVaccination coverageFamily medicineCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre survey; Immunology and Allergy; Immunology; PharmacologyMulticenter surveyFemalebusinesscoverage rateResearch PaperHuman
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Infliximab and newly diagnosed neoplasia in CD:a multicenter matched pair study

2006

Background and aims: The widespread use of anti-tumour necrosis factor α antibody (Infliximab) in Crohn's disease (CD) raises concerns about a possible cancer risk in the long term. In a matched pair study, we assessed whether Infliximab is associated with an increased risk of neoplasia. Methods: In a multicentre matched pair study, 404 CD patients treated with Infliximab (CD-IFX) were matched with 404 CD patients who had never received Infliximab (CD-C). Cases and controls were matched for sex, age (±5 years), site of CD, age at diagnosis (±5 years), immunosuppressant use, and follow up. New diagnoses of neoplasia from April 1999 to October 2004 were recorded. Results: Among the 404 CD-IFX…

Crohn's disease anti‐tumour necrosis factor α antibody Infliximab neoplasia multicentre matched pair study
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Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational S…

2018

Background. Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time.Methods. The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain.Results. 319 fractures (88%) healed within 12 months from treatment. Fo…

MaleGenetics and Molecular Biology (all)Immunology and Microbiology (all)lcsh:MedicineTibia fracture multicentre observational studyTibia Fracturefracture; healing; tibiaBiochemistry0302 clinical medicineOsteogenesisMedicineAdolescent; Adult; Female; Fracture Healing; Humans; Male; Middle Aged; Osteogenesis; Prospective Studies; Reproducibility of Results; Tibia; Tibial Fractures; Treatment Outcome; Young AdultProspective Studies030212 general & internal medicineYoung adultProspective cohort studyFracture Healing030222 orthopedicsGeneral MedicineMiddle Agedtibia fractureTreatment OutcomeAdolescent; Adult; Female; Fracture Healing; Humans; Male; Middle Aged; Osteogenesis; Prospective Studies; Reproducibility of Results; Tibia; Tibial Fractures; Treatment Outcome; Young Adult; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)Femaletibia fracturetibia FRACTure prediction healINGResearch ArticleAdultmedicine.medical_specialtyArticle SubjectAdolescentBone healingGeneral Biochemistry Genetics and Molecular BiologyNOYoung Adult03 medical and health sciencesHumansIn patientTibiaTime rangetibia FRACTure prediction healINGTibiaGeneral Immunology and Microbiologybusiness.industrylcsh:RReproducibility of ResultsSurgeryTibial FracturesObservational studybusinessBiochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all)
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Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

2012

The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2…

MalePediatricsCross-sectional study95% CI 1.19-1.59) from 1998-2000 to 2007-2010but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthmaAbstract The prevalence of asthma increased worldwide until the 1990stemporal trendsSurveys and QuestionnairesEpidemiologySurveys and QuestionnaireMedicineasthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in ItalyYoung adultrespectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38from 10.1% to 13.9% and from 16.8% to 25.8%education.field_of_studyAllergic rhinitis; Asthma; Epidemiology; Prevalence; Temporal trends; Wheezing;medicine.diagnostic_testSmokingthe median prevalence of current asthmaallergic rhinitis asthma epidemiology prevalence temporal trends wheezingItalyAbstract The prevalence of asthma increased worldwide until the 1990s but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010; n=10494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010 the median prevalence of current asthma wheezing and allergic rhinitis increased from 4.1% to 6.6% from 10.1% to 13.9% and from 16.8% to 25.8% respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38 95% CI 1.19-1.59) from 1998-2000 to 2007-2010 mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs asthma prevalence has increased by 38% in parallel with a similar increase in asthma-like symptoms and allergic rhinitis.mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrssymbolsasthma prevalence has increased by 38%FemaleepidemiologyHumanPulmonary and Respiratory MedicineAdult494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010in parallel with a similar increase in asthma-like symptoms and allergic rhinitismedicine.medical_specialtyRhinitis Allergic PerennialPopulationprevalencethe Italian Study on Asthma in Young Adults (ISAYA) (1998-2000Settore MED/10 - Malattie Dell'Apparato Respiratorio031)and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010Settore MED/01 - Statistica Medicasymbols.namesakeYoung AdultAllergic rhinitiHumansRespiratory soundsPoisson regressioneducationAsthmaRespiratory SoundsCross-Sectional Studieallergic rhinitisbusiness.industrywheezingwheezing and allergic rhinitis increased from 4.1% to 6.6%Rhinitis Allergic Seasonalasthmain the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993medicine.disease873)Cross-Sectional Studiesn=10Relative riskTemporal trendRespiratory Soundn=6n=18business
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Outcomes of interventional sialendoscopy for obstructive salivary gland disorders: an Italian multicentre study

2016

Sebbene le tecniche scialoendoscopiche abbiano assunto un ruolo fondamentale nel trattamento delle patologie ostruttive dei dotti salivari, in letteratura sono riportati pochi studi multicentrici sull’argomento. Questo studio basato sull’esperienza di 9 centri italiani è stato con-dotto su 1152 pazienti (553 donne, età media di 50 anni) per un totale di 1342 procedure scialoendoscopiche, il 44,6% delle quali a carico della ghiandola parotide. Il 12% dei pazienti è stato sottoposto a più interventi. I calcoli salivari sono risultati essere la principale causa di ostruzione (55%), seguiti dalle stenosi e altre malformazioni duttali (16%), dai tappi mucosi (14,5%) e dalla scialodochite (4,7%).…

MaleSialodochitisSalivary ductTherapeutic Procedure0302 clinical medicineOtologySialolithiasiMedicineSialolithiasisendoscopic surgery; multicentre study; salivary ducts; salivary glands; sialendoscopy; sialoadenitis; sialolithiasis030223 otorhinolaryngologyChildSialoadenitiAged 80 and overSalivary glandSalivary ductsSialoadenitisOtorhinolaryngology2734 Pathology and Forensic MedicineMiddle AgedParotid glandGeneral Energymedicine.anatomical_structureTreatment OutcomeItaly030220 oncology & carcinogenesisChild PreschoolSalivary DuctsFemaleAdultmedicine.medical_specialtyAdolescentSalivary glandsMulticentre studySialadenitis03 medical and health sciencesYoung AdultHumansSialendoscopyAgedRetrospective Studiesbusiness.industryEndoscopic surgery; Multicentre study; Salivary ducts; Salivary glands; Sialendoscopy; Sialoadenitis; Sialolithiasis;Salivary Gland DisorderEndoscopymedicine.diseaseEndoscopic surgerySurgeryStenosisOtorhinolaryngologySalivary Gland DiseasesSalivary Duct Calculibusiness
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Eribulin mesylate use as third-line therapy in patients with metastatic breast cancer (VESPRY): a prospective, multicentre, observational study

2019

Background: In real-world practice, eribulin mesylate provides significant survival benefit, with a manageable safety profile in heavily pretreated patients with metastatic breast cancer (MBC). Methods: In this prospective, open-label, multicentre, observational study we evaluated the effectiveness and tolerability of eribulin as third-line treatment in a homogeneous population. The primary endpoints were the safety profile and response in metastatic sites; secondary endpoints included the response in different subtypes, overall response rate (ORR), progression-free survival (PFS) and overall survival (OS). Results: From 2013 to 2016, 118 women were treated in 21 Sicilian institutions; the …

OncologyEribulin Mesylatemedicine.medical_specialtymulticentreThird-line therapylcsh:RC254-282chemistry.chemical_compoundInternal medicinemedicineIn patienteribulin metastatic breast cancer multicentre prospective real world third lineeribulinthird lineOriginal Researchbusiness.industryreal worldprospectivemedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensMetastatic breast cancerSafety profileSurvival benefitOncologychemistryObservational studymetastatic breast cancerbusinessEribulinTherapeutic Advances in Medical Oncology
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THE EUROPEAN SLEEP APNOEA DATABASE (ESADA) -- Report from 22 European Sleep Laboratories

2011

The European Sleep Apnoea Database (ESADA) reflects a network of 22 sleep disorder centres in Europe enabled by a COST action B26 programme. This ongoing project aims to describe differences in standard clinical care of patients with obstructive sleep apnoea (OSA) and to establish a resource for genetic research in this disorder. Patients with suspected OSA are consecutively included and followed up according to local clinical standards. Anthropometrics, medical history, medication, daytime symptoms and sleep data (polysomnography or cardiorespiratory polygraphy) are recorded in a structured web-based report form. 5,103 patients (1,426 females, mean±SD age 51.8±12.6 yrs, 79.4% with apnoea/h…

Pulmonary and Respiratory MedicineAdultMalePediatricsmedicine.medical_specialtyAdolescentDatabases FactualCross-sectional studyPolysomnographyComorbidityCohort StudiesSleep Apnea SyndromesRisk FactorsSurveys and QuestionnairesmedicineHumansMedical historyRespiratory systemAgedSleep disordermedicine.diagnostic_testAnthropometryModels Geneticbusiness.industrycomorbidity European Sleep Apnoea Database genetic multicentre cohort obstructive sleep apnoea syndromeCardiorespiratory fitnessMED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLAREAnthropometryMiddle Agedmedicine.diseaserespiratory tract diseasesObesity MorbidEuropeCohortFemaleHuman medicinebusiness
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